Shoreditch House’s collection was originally curated in 2007 by Francesca Gavin and includes a large number of small monochromatic artworks in a salon style that reflected the burgeoning east London art scene. Established artists include Cornelia Parker, Cerith Wyn Evans, Damien Hirst, Fiona Banner, Gavin Turk, Juergen Teller, Keith Coventry, Michael Landy, Oscar Murillo, Mike Nelson, Phyllida Barlow, Prem Sahib, Rachel Whiteread, and Toby Ziegler.

In 2020, artworks by a new generation of artists added colour to the walls with works by Matthias Garcia, Joy Labinjo, Sola Olulode, Hester Finch, Adam Bridgland, Lucy Gough, Leon Pozniakow, May Hands, Nwando Ebizie, Charlotte Edey, Sarah Maple, Nick Jensen, Dawn Beckles, Eliza Hopewell, Gommie, Kristy M Chan, Miranda Forrester, and Tom Howse. The collection also includes original new paintings, sculpture and photography by established artists Mary Ramsden, Clare Woods, Sunil Gupta, and Phoebe Collings-James.